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By Wen G. Jiang, R.E. Mansel

This publication covers the molecular and mobile points of melanoma metastasis, and discusses the medical point of micro- and macro-metastases, which lead to the demise of the vast majority of sufferers with melanoma. the present version makes an attempt to check the present prestige of the fundamental clinical and medical examine within the region, and is a truly invaluable reference for clinicians, oncologists, and biologists. it really is meant for undergraduates in addition to postgraduates within the quarter of medication, oncology, and melanoma biology.

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2 [see comments]. Science 1995; 268:884-6. 102. Gao AC, Lou W, Dong JT, Isaacs JT. CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13. Cancer Res 1997; 57:846-9. 103. Ueda T, Ichikawa T, Tamaru J, et al. Expression of the KAI1 protein in benign prostatic hyperplasia and prostate cancer. Am J Pathol 1996; 149:1435-40. 104. Rubinstein E, Le Naour F, Lagaudriere-Gesbert C, Billard M, Conjeaud H, Boucheix C. CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins.

Attempts to understand metastasis formation II: regulatory factors. Berlin: Springer-Verlag, 1996:215-232. 91. Freije JM, MacDonald NJ, Steeg PS. Nm23 and tumour metastasis: basic and translational advances. Biochem Soc Symp 1998; 63:261-71. 29 92. Leone A, Flatow U, VanHoutte K, Steeg PS. Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity. Oncogene 1993; 8:2325-33. 93. Bhujwalla ZM, Aboagye EO, Gillies RJ, Chacko VP, Mendola CE, Backer JM.

42 We have shown that MEK1 transformants show an increase in MMP2 and MMP9 activities (67), two matrix metalloproteinases that have been implicated in metastasis (68-73). We also observed an increase in the expression of cathepsin L (67), which also has been correlated with metastatic potential in ras-transformed cells (74, 75). One way that cathepsin L may lead to an increase in metastatic potential is by allowing the transformed cells to evade the, immune response by cleavage of the third component of complement (76).

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