By Vaccaro R.
With contributions from greater than a hundred popular specialists within the box, this reference compiles remedy ideas and information for a myriad of problems linked to nonoperative and operative administration of varied spinal pathologies in young ones and adults-providing specialist tips on hassle identity, reputation, administration, and prevention, in addition to the felony and moral points of latest spinal care.
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Extra resources for Complications of Pediatric and Adult Spinal Surgery
Safety Issues The supraphysiological doses of BMPs required to induce biological eﬀects in pre-clinical and clinical trials is an issue that raises safety concerns. The rhBMP-2 dose-response curve in humans is steep relative to that reported in animal fusion models, and large doses are required to achieve arthrodesis reliably. The use of milligram quantities of osteogenic proteins during procedures that involve extensive exposure of raw bone surfaces and other nonbony tissues that are known to have cellular receptors for BMP has resulted in untoward eﬀects.
32. 3 Complications of Bone Graft Harvest, Allograft Bone, and Bone Graft Extenders or Alternatives in Spinal Surgery Jim A. Youssef and Virginia M. A. I. AUTOGENOUS BONE GRAFTS A. Properties of Autogenous Bone Grafts Approximately 500,000 bone-grafting procedures are performed annually in the United States, half of which are associated with spine fusion surgeries. Autogenous bone is the historical gold standard for providing the requisite osteoinductive, osteogenic, and osteoconductive elements for bone graft consolidation.
Plast Reconstr Surg 2000; 105(3):980–990. 32. Kim CW, Abrams R, Lee G, Hoyt D, Garﬁn SR. Use of vascularized ﬁbular grafts as a salvage procedure for previously failed spinal arthrodesis. Spine 2001; 26(19):2171–2175. 33. Krishnan KG, Miller A. Reconstruction of the cervical spine using free vascularized bone. Eur Spine J 2002; 11(2):176–183. 34. Deen HG, Zimmerman RS, Lanza LA. Vascular pedicle rib graft in anterior transthoracic fusion procedures. J Neurosurg 1999; 90(1S):155–158. 35. Chugh S, Marks DS, Mangham DC, Thompson AG.