Download Enantioselective Chemical Synthesis. Methods, Logic, and by Elias J. Corey, Laszlo Kurti PDF

By Elias J. Corey, Laszlo Kurti

Written through world-renowned and best-selling specialists, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis deals an authoritative and entire assessment of the field’s growth; the strategies and instruments for key formations; destiny improvement for advanced, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and necessary examples of multi-step syntheses. using a color-coded scheme to demonstrate chemical changes, Enantioselective Chemical Synthesis offers transparent rationalization and counsel via important asymmetrical syntheses and perception into the subsequent steps for the sphere. Researchers, execs, and teachers will reap the benefits of this important, thorough, and special source.

  • In half I, the authors current sincerely, comprehensively and concisely the main important enantioselective procedures on hand to man made chemists.
  • Part II offers an intensive dialogue of the main logical how you can practice those new enantioselective the way to the making plans of syntheses of stereochemically advanced molecules. This hitherto overlooked zone is key for the development of enantioselective synthesis to a extra rational and strong point.
  • Part III describes intimately many response sequences that have been used effectively for the development of a wide selection of advanced aim molecules
  • Clearly explains stereochemical synthesis in idea and practice
  • Provides a great tool field for scientists wishing to appreciate and practice chiral chemical synthesis
  • Describes virtually 50 actual existence examples of uneven synthesis in perform and examines how the chiral facilities have been brought at key artificial stages

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Extra info for Enantioselective Chemical Synthesis. Methods, Logic, and Practice

Example text

Practical synthesis of enantiopure γ-amino alcohols by rhodium-catalyzed asymmetric hydrogenation of β-secondary-amino ketones. Angew. , Int. Ed. 2005, 44, 1687-1689. , Murata, K. & Ikariya, T. Practical Synthesis of Optically Active Amino Alcohols via Asymmetric Transfer Hydrogenation of Functionalized Aromatic Ketones. J. Org. Chem. 2002, 67, 1712-1715. , Noyori, R. & Ikariya, T. Practical Synthesis of Optically Active Styrene Oxides via Reductive Transformation of 2-Chloroacetophenones with Chiral Rhodium Catalysts.

Hydrosilylation of carbonyl and imino groups. Compr. Asymmetric Catal. -F. & Bette, V. Chemo- and enantioselective hydrosilylation of carbonyl and imino groups. An emphasis on non-traditional catalyst systems. Curr. Org. Chem. 2002, 6, 913-936; (c) Nishiyama, H. Hydrosilylations of carbonyl and imine compounds. , Mostefai, N. & Courmarcel, J. Recent advances in the asymmetric hydrosilylation of ketones, imines, and electrophilic double bonds. Synthesis 2004, 2943-2958; (e) Rendler, S. & Oestreich, M.

Enantioselective route to a key intermediate in the total synthesis of ginkgolide B. Tetrahedron Lett. 1988, 29, 3201-3204. -J. & Corey, E. J. Conversion of Torgov's Synthesis of Estrone into a Highly Enantioselective and Efficient Process. J. Am. Chem. Soc. 2007, 129, 10346-10347. Hong, C. , Kado, N. & Overman, L. E. Asymmetric synthesis of either enantiomer of opium alkaloids and morphinans. Total synthesis of (-)- and (+)-dihydrocodeinone and (-)- and (+)-morphine. J. Am. Chem. Soc. 1993, 115, 11028-11029.

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