By Jerome Engel Jr, Timothy A. Pedley MD, Jean Aicardi MD FRCP, Marc A. Dichter MD PhD, Solomon Moshé MD, Emilio Perucca MD, Michael Trimble MD
Written and edited by way of world-renowned experts, this three-volume paintings is, to cite a reviewer, "the definitive textbook approximately seizures and epilepsy". This moment version is punctiliously up-to-date and offers you a whole print and multimedia package deal: the three-volume set plus entry to an built-in content material site. greater than three hundred chapters disguise the spectrum of biology, body structure, and scientific info, from molecular biology to public wellbeing and fitness issues in constructing nations. integrated are targeted discussions of seizure varieties and epilepsy syndromes; relationships among body structure and scientific occasions; psychiatric and scientific comorbidity; stipulations which may be flawed for epilepsy; and an expanding diversity of pharmacologic, surgical, and replacement cures, together with vagus nerve stimulation and deep mind stimulation. This variation describes many new antiepileptic medicinal drugs, significant advances in surgical procedure, and cutting-edge neuroimaging, EEG, and different applied sciences for analysis and seizure prediction. A significant other web site bargains immediate entry to the full, totally searchable textual content, plus a picture financial institution of extra figures, video photos, and annual updates to chose chapters.
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Additional resources for Epilepsy: A Comprehensive Textbook (3-volume set)
Epilepsy Is More Than Seizures There have been many attempts to obtain a consensus on definitions of epileptic seizure and epilepsy. â This definition acknowledges that previous concepts of decreased inhibition and increased excitation were oversimplifications, because inhibition is actually increased in some forms of epilepsy where phasic inhibition is a central element in the primary epileptogenic abnormality. An epileptic seizure can also be a natural response of the normal brain to transient disturbance in function and, therefore, not necessarily an indication of an epileptic disorder.
13. Lennox WG. Epilepsy and Related Disorders. Boston: Little, Brown; 1960: 532â 574. 14. LÃ¼ders HO, Engel J Jr, Munari C. General principles. In: Engel J Jr, ed. Surgical Treatment of the Epilepsies. New York: Raven Press; 1993:137â 153. 15. Murray CJL, Lopez AD, eds. Global Comparative Assessment in the Health Sector; Disease Burden, Expenditures, and Intervention Packages. Geneva: World Health Organization; 1994. 16. Noebels JL. The biology of epilepsy genes. Annu Rev Neurosci. 2003;26:599â 625.
Additional complexities entailed in family studies of epilepsy are addressed in the review of electroencephalographic (EEG) traits in Chapter 16. Many EEG patterns are clearly inherited, often as a single-gene trait. The relationship of these patterns to clinical epilepsy, however, is elusive. The failure to distinguish between familial aggregations of EEG patterns and familial aggregations of seizures or epilepsy continues to cause confusion and would appear to be an important area for further study.