Download Principles of molecular neurosurgery by A. Freese, F.A. Simeone, P. Leone, C. Janson, L.D. Lunsford PDF

By A. Freese, F.A. Simeone, P. Leone, C. Janson, L.D. Lunsford

The way forward for neurosurgery might be characterised by way of much less invasive, molecular applied sciences that promise to revolutionize the sphere of neurosurgery and effect the remedy of extra neurological issues, together with neurometabolic ailments, stroke, dementias, affective and psychiatric ailments, flow problems, epilepsy, and others. This e-book encompasses constructing an knowing of the rules underlying the arrival of novel molecular techniques to neurological and neurosurgical illnesses. It Identifies key ideas that might let dramatic development within the therapy and results of sufferers struggling with a varity of problems affecting the principal anxious approach and spinal axis. This quantity offers neurosurgeons a great realizing of the improvement of novel molecular and mobile applied sciences that might markedly swap the way in which neurosurgery is practiced within the close to destiny. it's also of detailed curiosity to neurologists, psychiatrists, physiatrists, spinal orthopeadic surgeons, neurobiologists and gene remedy learn scientists.

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Ariga K, Yonenobu K, Nakase T, et al: Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs. Spine 2003;28:1528–1533. Gruber HE, Norton HJ, Hanley EN Jr: Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine 2000;25:2153–2157. Antoniou J, Steffen T, Nelson F, et al: The human lumbar intervertebral disc: Evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration.

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59] documented an increased incidence of disc degeneration among the family members of patients requiring lumbar surgery. Disc degeneration has been found to be significantly more prevalent in siblings of patients with disc degeneration than in random population samples [60]. Twin studies by Sambrook et al. [61] have shown a strong heritable component to disc degeneration in both the cervical and lumbar regions. Genetic studies have identified molecular defects contributing to disc degeneration in certain subgroups of patients.

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